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Elevated intake of BAs results in changes of the gut microbiota by means of inhibition of Actinobacteria and Bacteroidetes [22, 44].
Whether this exposure results in inflammatory and or developmentary changes of the gut of preterm babies is subject of the current study.
Workflow to probe functional changes of the gut microbiome.
In addition, in patients with obesity, changes of the gut microbiota were observed, which in itself can be an inflammatory factor that contributes to IR [ 47- 49].
The maintenance and compositional changes of the gut microbiota are known to be closely linked to human physiology, nutrition, and the prevalence of disease.
Despite minor discrepancies between individual studies, evidence is mounting that T2D is associated with both functional and compositional changes of the gut microbiota.
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We are now able to measure the impact of these changes on the gut microbiota diversity.
Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism.
In order to explore the age-related changes of the human gut microbiome, we applied Illumina shotgun sequencing to 9 fecal samples, whose microbiota composition was reported in a previous study [ 8], including centenarians, individuals at the upper extremity of the human lifespan [ 21].
More investigations with focus on various taxonomic levels (family, genus and species) of bacteria are necessary to clarify the exact relevance of changes in the gut microbial communities with the progression of T2DM disorder.
To study the effects of changes in the gut microbiota and improved barrier function on the one hand, and metabolic disorders on the other hand, we first assessed systemic inflammation.
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