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Topiramate, which modulates glutamate transmission, might thus reduce headache frequency mainly producing functional changes of the complex activity of this cortex.
For this purpose a new method based on the relationship between the kinetics of the macro-radicals coupling [Rcc(t)] was derived from a fundamental kinetic model and the viscoelastic changes of the complex shear modulus (G′(t)ω and G″(t)ω).
Multiple levels are involved including gene transcription, protein expression and posttranslational protein modification, all resulting in changes of the complex metabolic network that determines how cells perform specific tasks.
Moreover, changes in biochemical expressions and localization were correlated to morphological changes of the complex.
Genetic polymorphisms of such cofactor(s) may cause conformational changes of the complex, which allows RUNX3-bound TCF4 to bind the Wnt target gene promoter.
Little is known about two additional subunits, Scc3 and Pds5, and about possible conformational changes of the complex during the cell cycle.
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On the other hand, the electrostatic component of binding, which is mainly responsible for entropic change of the complex formation, changes significantly on changing the experimental salt concentration.
The overall conformational change of the complex indicates that TALE repeats may retain structural flexibility even after binding to DNA.
The change of the complex shear modulus during the film growth and during the doping/dedoping were calculated using the acoustic impedance method.
The total accessible surface area change of the complex compared to those of experimentally determined antigen antibody complexes indicates an intermediate size contact surface.
Where ?G? is the free energy change of the complex (kJ mol?1), R the gas constant (1.987 cal?mol?1 deg 1), T the temperature in Kelvin (273?+ C) and K c is the association constant of drug-acceptor complexes (1 mol?1 mol
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