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We further used the obtained regulatory network to predict expression changes of signature genes in three independent brain tumor cohorts (41 PA I from [ 46], 465 low grade gliomas including 50 AS II and 104 AS III from TCGA LGG, 553 GBM IV from TCGA GBM [ 23], see Additional file 2: Text S4 for details).
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Treatment with TGF β1 changes expression of signature miRNA and EMT proteins and modulates migration in lung cells.
The complexity of proportions prompted Cage to use asymmetric musical phrases and somewhat frequent changes of time signature to achieve both microscopic and macroscopic correlation.
Experimentation is evident in Grainger's earliest works; irregular rhythms based on rapid changes of time signature were employed in Love Verses from "The Song of Solomon" (1899), and Train Music (1901), long before Stravinsky adopted this practice.
Our results provide several markers of the steady state adult epicardium, and changes of epicardial signature gene expression in response to LCA injury that underscore the involvement of the epicardium after cardiac damage.
In one situation, in different cohort patients, a cancer-associated pathway could be affected by the co-expression changes of different signature hubs with the same set of neighbours enriched in this pathway.
In another situation, a cancer-associated pathway could be affected by changes of different signature hubs interacting with different sets of neighbours that were separately enriched in this pathway.
Next, we used the 151 differentially expressed TFs from the molecular signature (Fig. 6, Additional file 1: Table S3) to learn a transcriptional regulatory network that best explained expression changes of all signature genes distinguishing PA I from AS II, AS III and GBM IV (Fig. 7, Additional file 1: Table S4).
Although changes of electrical signatures associated with the introduction of microbial cells have been observed [52], no clear evidence of microbial effect was observed during phase II when the microbial activity was stimulated with molasses.
AS predominantly occurs co-transcriptionally, which may influence the regulation of splicing by changes of epigenetic signatures such as histone modifications and DNA methylation [ 24, 25, 60].
For instance, changes of EEG signatures observed after administration of experimental compounds can be assigned to the interference of drugs with certain neurotransmitter systems, such as the cholinergic, dopaminergic, and noradrenergic systems [ 20- 23].
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