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Unlike the results reported by Tan [ 5], the improvement of HFS-36 scores was not proportional to the changes of severity scales in our study.
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However, the spread of the disease did not result in a change of severity in Germany over time.
The purpose of this investigation is to provide a 'proof-of-concept' that the simulation technique can model individual patients whose aggregated disease course reproduces the rate of change of severity of illness, and the actual outcomes of a multicenter cohort of patients at risk for severe sepsis.
The paper by Saka and colleagues, however, included additional data from the clinical course before they entered the intensive care unit (age, gender, and ethnicity), thus 'recreating individual patients' whose entire disease course reproduced the rate of change of severity of illness.
The increased score value ('3' in this example) was used as the reference level (S1, i in equation (1)) for subsequent visits to describe any relative change of severity (decrease or increase) with respect to the visit of addition (the 'reference visit').
Simulated COPD lung changes of varying severity were represented by eight different non-homogeneous activity distributions.
Changes of the severity of uUTI symptoms from baseline were analysed by the Wilcoxon-rank test.
Data from the LSSS were also compared with physician-rated changes of seizure severity.
To further examine the changes of the severity of traumatic symptoms, paired sample t test was conducted.
Besides, we will evaluate the impact of self-compassion on changes of symptom severity.
Tan et al adopted patient's self-perception as part of the response of treatment, whereas we only used the changes of spasm severity as treatment response.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com