In each category with more than five changes of regimen IR's and corresponding 95%CI and IRR's and corresponding 95%CI adjusted for the same confounders as mentioned above in the analyses of IRR.
For example, it is not possible to compare treatment outcomes among patients receiving different treatment regimens due to the range of resistance profiles and variety of regimens (with changes throughout treatment) used.
All reported increased telephone contacts and home and school visits with more frequent insulin dose adjustments, change of regimen, and diabetes education.
Alternatively, a therapeutic regimen that has been used for treatment of the malignant disease may be the cause of the rheumatic complaints; in that case, discontinuation and change of regimen would be the optimal approach.
Reporting may primarily target serious or treatment threatening/limiting (treatment discontinuation, change of regimen, life-threatening event, hospitalization, poor adherence because of toxicity or death) ADRs rather than the notification of any suspected reaction.
This is in contrast to the studies by Manosuthi et al. and Van Leth et al. which demonstrated a higher rate of hepatotoxicity in patients receiving nevirapine requiring change of regimen [ 9, 11].
Information was documented on clinical characteristics such as WHO HIV stage, opportunistic infection, diagnosis of clinical depression, toxicity that warranted change of regimen, adherence to ART and CD4 + T lymphocyte counts.
By the six-month visit, 94 % of the patients on NVP had an adherence ≥95% and 933 % of the patients on the EFV regimen had adherence ≥95%% (p = 0.922).> Among patients who received EFV, 18 (2.8 %) had drug reactions that warranted a change of regimen, 10 (2.1 %) changed from EFV, eight (1.7 %) had hypersensitivity skin reactions, and two (0.4 %) had severe dizziness.
Adaptations to the regimen (i.e., dose reduction or change of regimen) were applied when necessary on the basis of the occurrence of adverse events during therapy as defined by the Common Terminology Criteria for Adverse Events (CTCAE) and the Common Toxicity Criteria.
Genotypic monitoring of drug-resistance mutations (DRMs) in HIV-1 infected individuals is strongly recommended to guide selection of the initial antiretroviral therapy (ART) and changes of drug regimens.
