WASHINGTON — Defense Secretary Robert M. Gates has told his military aides not to wear combat fatigues to work at the Pentagon anymore, reversing a symbolic change of protocol ordered in the harrowing days after the Sept. 11 attacks.
Various treatment plans and a change of protocol have been suggested for "low responders"; however, patients who fail treatment repeatedly inspite of good quality embryos pose a special therapeutic challenge.
This paper presents data for the preliminary group of mothers, enrolled before the change of protocol.
A single low mid-luteal progesterone concentration (suggestive of anovulation) could be attributed to a mistimed blood test and, given the pragmatic nature of the trial, did not result in a change of protocol.
Now, DEA also has to weigh in on changes of scientific protocol, and that can really slow things down, says Vandrey of Johns Hopkins, who is collaborating on a study there to compare the analgesic effects of cannabis and the opioid drug hydrocodone in healthy subjects.
Administrative changes of the protocol are minor corrections and/or clarifications that have no effect on the way the study is to be conducted.
Changes of the protocol, qualitative analyses, also recommended by the MRC guidelines, and the definitive, primary end point were then included in the final PRF.
BoHV-1: Bovine herpesvirus type 1 gB: Glycoprotein B OPD: orthophenyldiamine OD N : Mean optical density of the negative control sera OD P : Mean optical density of the positive control sera OD S : Mean optical density of the sample sera Changes of the protocol to adapt the kit to reindeer are depicted in italic.
The variety in the protocols stem from changes of trial protocols made during the long recruitment times and age-adjusted treatment regimens.
Since direct pharmacokinetic measurements in the human cochlea are not possible, simulations provide a valuable tool for the interpretation and planning of animal studies, for evaluating changes of application protocols and drug delivery systems, and for extrapolating the results from animal studies to the human.
