Sentence examples for changes of mutant from inspiring English sources
the changes of mutant allele frequency between tumor and normal should be statistically significant (Fisher's exact test, p < 0.05); ix.
We anticipated that discrete amino acid changes of mutant proteins might allow the identification of functionally important residues.
In conjunction with this, a series of simulations have given insight into the overall dynamics and conformational changes of mutant PON1.
Comparison of fold-change of mutant clones to wild-type (WT) parasites revealed that approximately 50% of the mutants (59 mutants) were significantly attenuated, with a reduced fold-change of >2 standard deviation (SD) from the mean of WT fold-change (P<0.05) (Fig. 2A) (Table S1).
Tiling microarray probes corresponding to both forward and reverse strands from each window were binned into ∼600 bp windows, and log2 fold-changes of mutant versus wild-type from duplicate arrays for each mutant strain in each window were averaged.
Values represent fold change of mutant to WT in peak area of identified metabolites at 5, 8, 12, and 16 DPA.
The free energy change (DDG) predicted by I-Mutant 3.0 is based on the difference between unfolding Gibbs free energy change of mutant and native protein (kcal/moL) [ 40].
Lopes and Simonson [ 54] compared a parametrised SASA model [ 25 ] to two GB models and showed that the former predicts the correct sign and order of magnitude of the stability change of mutants with a marginally higher error compared to the more accurate GB method.
Although PolyPhen-2 predicted probably damaging effect for this mutation, no conformational changes of the mutant protein were shown by PSIPRED program (Table 1).
This leads to three estimates of expression fold changes of the mutant versus the wild type.
To understand the molecular mechanisms involved, we need to investigate the temporal and tissue specific expression of tRNA modification enzymes, to find the targets of genes underlying the phenotypic changes of each mutant.
