Sentence examples for changes of histone from inspiring English sources
These data nicely demonstrate the dynamic and reversible changes of histone H3K4 methylation and H3 acetylation in responses to environmental changes in rice.
Glycolysis provides energy for growing lymph vessels, while fatty acid oxidation is a critical metabolic regulator of lymphangiogenesis, in part by promoting nucleotide synthesis as well as by mediating epigenetic changes of histone acetylation, which promotes transcription of key lymphatic genes, and hence venous-to-lymphatic endothelial cell differentiation.
These changes of histone acetylation allow chromatin open structure to recruit repressor binding to the hTERT 5'-regulatory region [15], [19].
Furthermore, in mouse embryos, dynamic changes of histone lysine methylation have been described to characterize the first cell cycle, which takes place prior to the zygotic transcription [59].
Consistent with the role of epigenetic control in a variety of behaviors, the time-scale of epigenetic regulation varies widely, from circadian changes of histone acetylation in the promoter regions of clock genes [4] to long-term memory formation [5].
For example, the first genome wide characterization of epi-toxicogenomic changes of histone acetylation profiles at a thirty five nucleotide resolution using Affymetrix Promoter Tiling arrays was reported [39].
Interestingly, there is evidence that the binding of NF-κB to its nucleosomal targets requires conformational changes of histones to render its binding sites accessible [ 78].
Thus, the ratio of AcH3/H3 or AcH4/H4 accurately reflects the change of histone acetylation.
We first used an antibody against acetylated histone H3 to detect the change of histone H3 acetylation level at the RTA promoter.
For example, the dynamic change of histone acetylation and deacetylation has been shown to drive the spliceosome assembly and rearrangement [ 32].
They may modify chromatin by inhibition of histone deacetylases without significant change of histone deacetylase transcription, thus their target genes do not necessarily occur in microarray studies as differentially expressed genes or at the top of a list of these.
