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But Roth's greatest strength is his ability to depict the mercurial changes of fate.
Along the way to a hopeful ending for Deronda (though not for Gwendolen), there are twists and turns and sudden changes of fate, including Deronda's rescue of a woman attempting suicide and, later, the death at sea of another character.
It's had numerous upsets, parity, perennial powers struggling, overtime thrillers and sudden changes of fate.
However, any changes of fate would be difficult to detect as we do not have useful markers for cell fate in that region of the cuticle.
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It's a happy change of fate for these dogs; for a while it looked like they might have been freed from abuse only to be euthanized by their rescuers.
Yet, numerous examples of 'spontaneous change of fate' exist in the old literature, but they are often linked to post-natal tissue damage and regeneration.
Given this, we proceeded to test if the observed transition between Lz− and Lz+ corresponds to a change of fate from plasmatocyte (phagocytic) to crystal cell (non-phagocytic).
Moreover, within the motor neuron progenitor domain, cells that downregulated Olig2 cell-autonomously upregulated Nkx2.2, indicating a change of fate from a motor neuron to a p3 progenitor (Fig. 3J-L″, n=6).
Ectopic expression of combinations of transcription factors can induce changes of cellular fate in adult pancreatic tissue (Zhou et al., 2008); however, examples of reprogramming in vivo by loss of a single molecule are rare.
Whether the change of hemocyte fate can cause an overgrowth in sensitized Zfrp8 null/+ lymph glands remains unclear.
Excess melanocytes can arise from increases in proliferation, change of cell fate of additional cells into melanocytes, or perhaps even failure of apoptosis.
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