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PAS-induced changes of cortical excitability share a number of physiological properties with LTP.
The mechanisms underlying transcranial direct current stimulation (tDCS) induced changes of cortical excitability and arousal remain to be fully characterized.
To avoid changes of cortical excitability due to hormonal variations, all female subjects performed the experiment in the first half of the menstrual cycle.
Recently, Sleimen-Malkoun et al. [12] used a battery of multiscale metrics, including variogram to investigate the changes of cortical dynamics with aging.
Other reports presented an increased fMRI activation and grey matter changes of cortical pain processing networks to further support an involvement of cortical structures[29, 21].
On the other hand deafferentation and activity dependent plasticity can induce changes of cortical as well as subcortical structures like thalamus and brainstem [91].
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We compared regional percentage change of cortical thinning and subcortical atrophy over 18 months.
In the longitudinal analysis, the per cent change of cortical thickness was the dependent factor and the diagnostic group was the independent factor.
For the longitudinal analyses of cortical thinning, vertex-wise comparisons of per cent change of cortical thickness among the diagnostic groups were analysed using the longitudinal two-stage GLM in Freesurfer (Reuter et al., 2012).
If both electrodes are placed on the scalp (bi-cephalic montage), it has been argued that observed tDCS effects may be due to a combination of facilitation and/or inhibition across the brain, giving rise to a widespread change of cortical excitability (Lang et al., 2005).
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