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Many cellular forces, for example, those generated in cyclic conformational changes of biological machines, have repetitive components.
Activated immune responses were among the major changes of biological function.
In the process of activation and proliferation of T lymphocytes, the variation of both cellular topography and membrane biophysical properties might correlate with the changes of biological function of T lymphocytes, such as the phosphorylation of signaling molecules, changes of cell polarity, and Ca2+ release [23 26].
How to translate the differentiation into changes of biological activities is another key problem in the functional genomics of ageing.
Questions about the changes of biological systems in response to hostile environmental factors are important but not easy to answer.
The common changes of biological activities in the differentiation are inferred by integrating the expression profiles with biological subsets defined by cellular organelles, metabolism pathways, biological process, and molecular functions.
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The change of biological communities over time is known as succession, or ecological succession.
In the central-eastern (170°W 140°W) equatorial Pacific, moderate change of biological activity is attributed to the changes of thermocline driven by the eastward propagating equatorial Kelvin waves and changes of zonal currents and undercurrents.
In the research of virus infection, Pichler et al. [ 28] and Zhao et al. [ 29] found that the change of biological distribution of fluorescein and coelenterazine could influence the imaging effect of HSV-1.
However, it is a well-known limitation of structure activity relationships that the absence or presence of a functional group or other minor change of the chemical structure may result in a large change of biological activity (Maggiora 2006).
Both absolute and % change [calculated as (2006/07)/(1996/97) × 100] of perch THg were regressed against physical characteristics of the lakes or against % change of biological or chemical variables that showed significant differences through time (simple GLM).
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