Sentence examples for changes of affinity from inspiring English sources
A possible but also not necessarily more precise alternative to judge indirect effects on drug binding would be to run free energy simulations with the bound drug to judge changes of affinity caused by the mutations but this is a tricky and time-consuming endeavour that would burst the scope of this current manuscript.
The change of affinity results from compromised selection of high affinity antibodies within the germinal center [ 19, 20].
Next, we tested how the receptor mutations change binding to IFN- γ and these ΔΔ G gauge the change of affinity.
However, greater flexibility of L2 in the complex, permitted by the mutation, might make this change rather neutral resulting in only a small change of affinity, as is observed.
Therefore, we calculated the MFE changes using the Ref-sequences and Alt-sequences with the miRNAs to evaluate the changes of binding affinity under SNP influence.
The signal transduction of the chemokines receptors leads to changes of the affinity and avidity of integrins on leukocytes to their specific ligands expressed on the endothelium by the so-called 'inside-out' signalling [ 48].
The explanation could be that diminishing the basic character of the terminal amino group may result in a change of its affinity towards the zinc ions.
It is plausible that a change of TCR affinity will not influence the extent of CD8 engagement with MHC class I molecules while a variation of epitope density will.
As shown in Figure S5 in the Supporting Information, as pH changed, the change of PDI affinity between ssDNA and dsDNA was negligible.
The triggered change of the affinity of the ionophore, the charge of the ion exchanger, or the p Ka of the indicator will suddenly allow for a controlled change in sensor characteristics in space and time.
Indeed, conformational changes linked to immobilization of an antibody can lead to steric hindrance or the alteration of the paratope region and therefore to a change of its affinity for the antigen.
