Sentence examples for changes linked to aging from inspiring English sources
All rely on molecular changes linked to aging, but must still overcome confounding factors such as individual variation and disease, which may speed or slow aging.
In this regard, monozygotic twins are a good model for studying epigenetic changes linked to aging: they provide evidence that these changes can accumulate over time, as one individual may gradually undergo alterations that his or her twin (with identical genotype) does not (Fraga et al., 2005; Schneider et al., 2010).
Intriguingly, the biological changes linked to ageing are potentially reversible, raising the prospect of future treatments that could arrest the ageing process and extend the human lifespan.
Indeed, the best example of an epigenetic change that may be linked to aging in mammals is decreased expression of sirtuin1 (SIresultinglting in the DNA damage-induced reorganization of chromatin (chromatin instability) (Sommer et al., 2006; Oberdoerffer et al., 2008).
Therefore, these changes are the basis for important alterations linked to aging [ 11- 15].
The changes, linked to raising the leaving age for education and training, will mean youngsters in the education system beyond 16 will be expected to reach an adequate level in maths and English.
As well as acquiring epigenetic changes linked to increased self-renewal and decreased differentiation (see above), aged HSCs also display such hypermethylation events characteristic of MDS.
"There is substantial evidence that we have done little to date to eliminate or delay disease or the physiological changes that are linked to age," the authors wrote.
Together, the observations discussed here suggest that ageing also deleteriously affects spinal neurons that govern bladder/bowel reflexes and continence and that these changes may be linked to ageing of CNS neurons.
