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Profound quantitative analysis of protein changes led us to the hypothesis that the cellular proteome is kept quantitatively in balance by a particular class of proteins to which we refer as "balancer proteins".
The requirement of Bax/Bak for PUMA to induce the mitochondrial changes led us to test whether expression of Bax alone would be able to mediate similar effects.
These subtle changes led us to suggest that one should consider caspase-3 conformational dynamics as containing active and inactive ensembles rather than a single active conformation and a single inactive conformation as in the two-state allosteric model.
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Unlike previous works, our work focuses on rate control and channel assignment in the ad hoc network context, and thus, maintaining network connectivity in dynamic network changes leads us to distributed hybrid channel assignment-based solutions implementable with lesser overhead.
A careful characterization of two cage types, including a comparison of the auditory and temperature environments, coupled with a demonstration that naris occlusion abolishes the neuroanatomical changes, lead us to conclude that a likely important factor mediating the phenotypic changes we find is the olfactory environment of the two cages.
Change leads us into the unknown.
The mention of "change" leads us quickly to another prevalent idea -- justice.
Alas, human-induced climate change leads us to this situation which forces us to think this way.
Our analysis of several cell shape changes leads us to propose four regulatory modules associated with ratchet-like deformations that are tuned to generate diverse cell behaviors, coordinating cell shape change across a tissue.
In the case of climate change this led us to investigate gradual changes in large scale climate variables such as globally averaged precipitation or the monthly mean temperature of a continent.
However, our commitment to ensuring that the experience and knowledge of persons with dementia is not overlooked in culture change efforts led us to more closely examine what meaningful engagement in PAR can look like for persons with dementia across the dementia journey.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com