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TG2 is a versatile multifunctional protein that changes its function depending on external and internal signals [24 26].
This radiator, reversible thermal panel (RTP), which consists of flexible high thermal conductive graphite sheets and a single crystal shape memory alloy as a passive reversible actuator, changes its function from a radiator to a solar absorber by deploying/stowing the reversible fin upon changes in the heat dissipation and thermal environment.
Our novel observations that in context of REDD1 KO cells GR changes its function could explain the improved therapeutic index of glucocorticoids (preserved therapeutic potential combined with reduced atrophogenic effects) in REDD1 KO animals.
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But if after RF shift the protein has changed its function, then it is of great interest to understand how changes in amino acid sequence determine the protein's new function.
For example, when the cytosolic protein IDE (insulin degrading enzyme) was engineered to relocalize to the mitochondria, it immediately changed its function from regulating plasma insulin levels to degrading peptides (Leissring et al. 2004).
"If Facebook wanted to enter China, it would not have to change its function, because netizens here are used to copycats already, but it must, like other international internet companies, obey Chinese laws and regulations," said Hu Yong, a professor at Beijing University's school of journalism and communication.
"The building has changed its function," says de Vaux.
But a new study fingers a third culprit: chemicals that attach to DNA and change its function.
This required the government to change its function and further establish systems of clear rights and responsibilities for managing, supervising, and running state assets to guarantee their maintenance and appreciation.
This indicated that one of the members changed its function during the course of evolution.
RFX1 is known to change its function by recruitment of the CYC8/TUP1 corepressor complex (Zhang and Reese, 2005).
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