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Therefore, changes in zinc availability alter numerous cellular processes.
In addition, we have explored some of the regulatory mechanisms that allow Mtb to survive within the host, such as DevR (DosR) regulon, which is a key element for understanding the dormant state, and the regulation of the response to changes in zinc availability (ZuR regulon).
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We argue that zinc regulation is not only tissue-specific but also time-dependent, such that groups of genes with distinct functionalities may be regulated at different time-points following a change in zinc availability.
The conclusion from this global analysis may be that the transcriptional adjustments in the gill required for acclimation to a change in zinc availability culminates within a week and acclimation is established by two weeks.
A decrease in zinc availability is associated with an increase in cellular oxidants, alterations in the antioxidant defense components, and increased oxidation parameters [ 25, 26].
Given zinc's many intracellular capabilities, we hypothesized that changes in zinc's subcellular localization occur during differentiation in hESCs.
Given such changes in zinc transporters, one might expect to see enhanced absorption of zinc in individuals with low zinc status.
There is no simple means to identify subclinical zinc deficiency or to relate health outcomes to changes in zinc status.
More work is needed to identify which zinc pools are sensitive to changes in zinc intake and bodily stress, or to zinc loss, especially in children who are at risk of zinc-deficiency related disorders.
In rats, ZnT-4 is expressed ubiquitously and was refractory to changes in zinc intake [ 16].
As previously demonstrated, Tau*C2A toxicity is relatively insulated from changes in zinc concentration.
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