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The major shortcoming of the current study is that it is based on a mixed cell population of leukocytes and genomic changes may reflect changes in this population.
Since the direct MS method was able to detect meaningful changes in this population, we hypothesize that the method will be robust to patient-to-patient variation and other sources of variability that would be commonly encountered in clinical application.
Future studies should evaluate decadal changes in this population.
Measuring cognitive changes in this population is challenging.
Future studies should examine the relationship between symptom severity and quadriceps neuromuscular changes in this population.
Recent FM research has described clinically relevant changes in this population for FIQ scores [ 10].
Similar(39)
These changes may be one of the initial parameters of weight control, occurring before BMI percentile change in this population.56 Parents in the experimental group showed an increase in waist circumference, although not as much as the control group and, similar to the children, they showed a significant decrease in skinfolds.
The QoL.BD is more sensitive to change in this population than commonly used generic QoL measures (Michalak and Murray 2010).
Furthermore, our experience indicates that the MHFMS scale alone is not adequate to measure motor function in ambulatory SMA subjects, prompting us to explore other measures to assess functional change in this population.
The difficulties bringing about change in this population may reflect the inherent problems in this population.
The maintenance of dietary changes at the 12-month follow-up are encouraging given the common negative attitudes toward dietary change in this population (13, 14).
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