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Nevertheless, changes in this connection similarly failed to predict clinical efficacy, thus this effect may not be key to the immediate therapeutic mechanism of STN-DBS.
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Nine changes in the connection domain and 6 in the RNase H domain were found related to treatment (Figures 2 and 3).
(C ) A schematic diagram illustrating the conformational changes in the connection' and RH' domains that are related to the observed resonance changes.
The rostrocaudal gradient of connectivity variability recovered in our study with LE was therefore expected to reflect changes in the connection probability with regions featuring different cortical types.
The analysis identified the advantages of a sectorally balanced, dynamic Nexus approach, in particular the ability to reveal either the emergence of cross-sectoral connections, or changes in those connections, as a consequence of single sector interventions.
We thought that changes in causal relationships among the symptoms would underlie the changes in the connections between symptoms.
Focal injury results in diffuse adaptive changes (Brion et al., 1989), including changes in the connections between network nodes (Grefkes et al., 2008; Sharma et al., 2009 b ).
A significant interaction (F 1,24) = 105.44, P < 0.0001) confirmed that the changes in the connections to the DMN nodes and the limbic system occur in the opposite direction.
Our systems-level approach clearly demonstrates that the connections between genes, and the changes in these connections associated with the physiological state, may be a more informative way to measure gene expression response to disease and/or environmental stimulus.
This could be achieved through the action of proteins at the protrusion neck, by an internal cytoskeleton, by structural changes in the S-layer (for example, local weakening), by changes in the connections between the S-layer and cytoplasmic proteins, and/or by changes in osmotic pressure.
These findings can be attributed to the activation of p38MAPK by oxidative stress, inflammatory mediators, hypertonic environment, mechanical stress in the nucleus, induced regeneration and reconstruction of F-actin by regulating the activity of HSP27, and changes in intercellular connection.
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