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Nevertheless, a more complete understanding of the evolution and epidemiology of dengue viruses, particularly with respect to predicting epidemics of more severe disease, requires large-scale prospective studies that compare phenotypic expression with genetic changes in the viruses (18, 19).
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Genetic changes in the virus could also be responsible.
The ability of SARS coronavirus to jump to humans undoubtedly required genetic changes in the virus.
But such changes in the virus would also mean that the vaccines now being developed, including ones more potent than Sanofi Pasteur's, would lose some effectiveness.
The ability of the SARS coronavirus to jump from horseshoe bats to humans undoubtedly required genetic changes in the virus.
They were thus able to track genetic changes in the virus over time, and watch it adapt to its new host species Homo sapiens.
The W.H.O. is tracking changes in the virus, trying to predict if it will mutate into a more infectious form and hoping to build vaccines against it in time to head off a pandemic.
The four global monitoring centres were established in 1948 because it was recognised that the composition of the flu vaccine, which had just been developed, would have to be changed to match the changes in the virus.
Despite reports this week that the virus may be mutating, scientists have yet to show that genetic changes in the virus are related to changes in its pathogenicity.Related items Hong Kong's economy: In intensive careApr 24th 2003 Canada's worries: UntouchableApr 24th 2003 China and SARS: China's Chernobyl Apr 24th 2003 The SARS epidemic: China wakes upApr 24th 2003.
Major hospital outbreaks have happened before without any apparent changes in the virus's genetic material.
The impact of genetic changes in the virus on human's susceptibility is an outstanding important question in vaccine design.
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