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No significant changes in the transduction profile were found after collagenase treatment.
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We did not find significant differences in the transduction profiles of Ad-L2 in adult mice following tail vein injection and retro-orbital injection (Supplementary Figure 2).
Previous studies have indicated that genetic alternations and changes in the transduction pathways are involved in CRC initiation and progression.
Neonatal/prepubertal exposure to BBP induced changes in the genomic profile of the mammary gland, mainly at the end of treatment (21 days) with a focus on genes involved in cell proliferation/differentiation, communication and signal transduction.
The changes at the mRNA level that we report do probably reflect changes in the signal-transduction network that mediates the adaptive changes in metabolism and cell turnover better than that they reflect the changes in protein levels.
Based on a preliminary study, we selected the AAV9 serotype because it showed the best transduction profile of the spinal cord following IT injection in adult mice.
It can be concluded that DNA conformational changes are determinant in the transduction process and that the electrostatic effect is negligible.
Thus, changes in the serum N-glycome profile may reflect pathological changes in the liver.
The changes in signal transduction that modulate metabolite flow, the cell cycle and apoptosis are presently being analyzed.
The changes in signal transduction induced by oxidative stress, in turn, influences the mitochondrial activity.
However, recent evidence deriving from neutrophils, showing multiple alterations in signal transduction during sepsis, favors the point of view that changes in signal transduction might be responsible for the observed changes in platelet aggregation [ 32].
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