The overall idea is that a significant change in the tendency of a protein region to be structured or disordered could lead to malfunction of such a protein.
In the final model, each joinpoint indicated a significant change in the tendency, and the APC was obtained in each of the segments delimited by the joinpoints, using the weighted least squares technique.
In other words, the occurrence of the initial event of spread does not lead to a cell-heritable change in the tendency of the progeny of that cell to spread.
The result of experiments suggests that a significant change in the tendency of a protein region to be structured or disordered caused by SNVs may lead to malfunction of such a protein and contribute to disease risk.
For example, from Figure 5 it is clear that when comparing median values (horizontal dashed lines in boxes) among ensembles, and for a given number of mutational combinations evaluated, no systematic behavior is observed with respect to changes in the overall tendency of epistasis.
The hypothesis that we want to test is that SNVs that cause changes in the structure/disorder tendency are deleterious.
Because we did not see changes in the reactivation tendency for cells, we next tested whether novelty-induced firing rate changes can be observed in our data, as shown before by Nitz & McNaughton (2004).
Conductivity composition isotherms are non-linear, indicating the change in the ordering tendency of the system.
Apart from the extent of change in the central tendency estimates, the increased specificity and in-depth evaluation presented here can reduce the level of uncertainty present in the existing U.S. EPA analysis.
Importantly, there was no change in this tendency before and after reinforcement of the guideline, suggesting that this was insufficient to improve sedation practice [ 3].
The magnitude of the structural changes in tendency parallels the solid-state instability data (i.e., formation of buffer-insoluble aggregates, inactivation, and loss of native conformation upon reconstitution).
