Sentence examples for changes in the safety profile from inspiring English sources
Development of antibodies against the medication may potentially lead to reduced efficacy and/or changes in the safety profile.
Changes in the safety profile of sorafenib over time (prevalence) were examined by assessing the occurrence of any DRAE (grades 1 4) in 3-month intervals.
20 However, there is no evidence suggesting that pre-exposure to a flavivirus could lead to change in the safety profile of YF vaccines.
The most striking change in the safety profile of the weekly docetaxel-based combination regimens used in this study was a substantially lower rate of myelosuppression and complicated neutropenia compared with that of 3-weekly TCF (Van Cutsem et al, 2006).
Although the number of patients is limited (n = 37), it is encouraging to note that, following dose increases to ≥30 mg/kg per d, there was no apparent change in the safety profile, in line with previous studies (Taher et al, 2009).
Physiologic changes during pregnancy may change the safety profile and efficacy of medications and vaccines for pregnant women.
The addition of another mRNA compound encoding the MUC1 antigen in CV9202 will correspond to a 20% increase in mRNA amount per vaccination; however, based on the dose-escalation experience in the phase I/IIa trial with CV9104 it is not expected that the dose of 1920 μg of mRNA in the current trial will significantly change the safety profile.
"We are confident in the safety profile of Crestor," said Rachel Bloom-Baglin, a spokeswoman for AstraZeneca.
There were no apparent differences in the safety profile of CPG−DDS alone or in combination with artesunate in this study and no artesunate dose-related changes in laboratory parameters were observed.
