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Taken together, the transcriptional reorganization observed in the regulatory networks was not only secondary to the expression changes in the regulators (e. g., rpoH) but also occurred in networks controlled by the regulators of steady expression (e. g., purR).
The latter case suggested either weakened transcriptional control by the regulators or a high level of sensitivity in the downstream genes (i. e., slight transcriptional changes in the regulators resulted in profound transcriptional changes in the downstream genes).
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Indeed, our model predicts a high responsiveness for all regulations in the endogenous system to changes in the regulator concentrations.
Changes in the regulator need not be the only source responsible for the entropy difference.
The overall picture suggests that the system operates in a state that is highly responsive to changes in the regulator concentrations.
Moreover, it does not take interdependence between genes into account and can mark an expression change as abnormal when actually it is induced by a change in the regulators' activity.
Changes in these regulators were consistent with increased apoptosis in tumors from ginseng-supplemented mice.
In addition sequencing was used to evaluate any changes in the positive regulator gene tcdR, the putative toxin secretory gene tcdE, as well as the putative negative regulator gene tcdC.
As shown in Figure 1C, the parameter sets leading to priming effect clearly cluster into two regions, in terms of the change in the two regulators, x1 and x2, at the end of LD pretreatment (Δ s s x i, L D, i = 1,2).
However, in many cases, if not most, transcriptional regulation of targets is not accompanied by changes in the levels of the regulators' transcripts, and even when it is, the changes don't have to be correlated with the transcription of the targets.
We also found the lack of changes in the level of the regulator of G protein signaling 4, which is a specific Gq/11α-dependent GTPase activating protein, in the limbic forebrain obtained from morphine-sensitized mice.
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