It is not known at present what changes in the mechanisms regulating glutamate release are affected by CORT.
Hippocampal neurons are highly plastic and respond to early environmental challenges with long-lasting changes in the mechanisms regulating synaptic plasticity and network organization, neurogenesis in the dentate gyrus, and the HPA axis [46], [47].
Most prominent are changes in the pathways regulating energy turnover, extracellular matrix and cytoskeleton, which could have a role in adipose tissue wasting.
A rapid weight gain pattern during early childhood ("adiposity rebound") and during sexual development in females are risk factors for obesity for many reasons (genetic predisposition, life-long changes in the appetite regulating centers, etc).
On Capitol Hill, where federal and state officials testified on Monday at a Senate hearing on the mutual fund industry, lawmakers have begun to call for significant changes in regulating the industry -- which is in its greatest turmoil since it came under federal oversight more than 60 years ago.
In addition, some of the changes observed here could depend on oncogenic changes in genes regulating the expression of multiple miRNAs, as demonstrated for C-MYC and BCL6.
In the wake of the collapse on the East Side, the city ordered sweeping changes in the way it regulated tower cranes and crane jumps.
Mr. Bloomberg said that the city needed to make changes in the way it regulates construction and turned to Mr. Green.
Sequestosome-1/p62 is a cargo receptor for selective autophagy [ 98] and changes in autophagy regulate the p62 level which controls the formation of protein aggregates as well as activation of NF-κB signaling [ 99, 100].
