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These results confirmed the role of bone changes in the pathogenesis of OA.
Child environment, an early stress and the mother-child relationship are important factors of epigenetic changes in the pathogenesis of migraine [42].
Although inflammation is an important component of renal fibrosis [158] the role of macrophage phenotype changes in the pathogenesis of these diseases has only just begun to be investigated.
The role of micro-vascular changes in the pathogenesis of OA warrants further investigation.
Recently, increasing numbers of studies have implicated chondrocyte terminal differentiation (hypertrophy-like changes) in the pathogenesis of OA.
Although the above findings support the importance of subchondral bone changes in the pathogenesis of OA, the hypothesis that these changes initiate idiopathic OA is still unproven.
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The metabolic change in the pathogenesis could negatively affect cellular C content based on the expression of sugar-repressive nuclear genes and may be involved in the regulation of these genes [ 63].
Although not tested for prognostic value, the findings revealed differential staining patterns with the two PSSAs, suggesting that high levels of Ser392 phosphorylation is an early change in the pathogenesis of SCC (Matsumoto et al. 2004).
The role of subchondral bone change in the pathogenesis of knee OA will need to be determined but may be one explanation for the mechanism of action of risk factors such as body mass index on knee OA.
The role of subchondral bone change in the pathogenesis of knee OA will need to be determined but may be one explanation for the mechanism of action of risk factors such as BMI on knee OA.
Here, we review the metabolic changes occurring in the pathogenesis of RA as well as the implication of the metabolic features in the treatment response.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com