Sentence examples for changes in the overall structure from inspiring English sources

The structural models of hCNT1 and hCNT3 suggest changes in the overall structure of the nucleo-pocket.

But they have been unable to agree on sweeping changes in the overall structure of Medicare, which would require the traditional government-run program to compete directly with private health plans.

Through interviews with the anthropologist on the management team and some changes in the overall structure of the program administration, resolution of the conflicts became possible.

Figure 9 represents how dramatic changes in the overall structure can become if the cost for a certain source is changed even slightly.

Since it was possible that mutations had disrupted tetramer formation and that changes in the overall structure might account for the reduced binding of γ-tubulin, we next analysed purified CTD containing these mutations by CD and MALS.

Our present data suggest no significant changes in the overall structure of the MyTH4 FERM cassette on DCC binding.

Each mutation led to a severely decreased catalytic efficiency without a change in the overall structure of the mutant enzymes.

However, it is now clear that mutation of C277 does not only abolishes transamidating activity but also significantly reduces guanine nucleotide binding likely due to a significant change in the overall structure of the protein [3], [20].

A comparison of the two sets of micrographs indicates there is no change in the overall structure of the TM with time in either the wild type (Fig.  3A and E) or mutant (Fig.  3B D, F H) mice.

Compared to the wild-type of N-Cby, the single point mutation does not lead to a dramatic change in the overall structure of the protein, judging from the overlay of the H−N HSQC and CD spectra of the wild-type and S20D mutant of N-Cby.

(B) Small structural variations in each repeat are amplified to prominent conformational changes seen in the overall structure in Fig. 4A.