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Furthermore, visual deprivation for five days also leads to dramatic changes in the overall excitability of occipital cortex (quantified by phosphene thresholds using TMS [45]).
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Since they operate in a voltage range where other channels are closed, even subtle changes in the activity of these channels can have large repercussions in the overall excitability and firing properties of the cells expressing them.
Relative changes in the calculated excitability index (see Methods) reflect changes in membrane potential [26] with an increase in excitability index representing axonal depolarization.
For example, changes in the classical excitability parameters (e.g., Rin, threshold) suggested increased excitability; whereas the capability to elicit high frequency firing is decreased.
We do not have TMS measures of cortical excitability in the subjects in the current paper, but we would not wish to argue that the expected increase in excitability was driven solely by GABA changes, or indeed that the magnitude of GABA changes and the degree of overall excitability increase were necessarily related in an individual subject.
Up to now, changes in the excitability of such pathways have not been documented after stroke.
These could be explained by corresponding opposite changes in the excitability of individual neurons.
However, to prevent such errors, postsynaptic neurons and synapses can adapt and counteract changes in the excitability of presynaptic neurons.
In this work, we evaluated whether ECT induces a measurable change in the excitability of frontal cortical circuits in humans.
Although unlikely, the possibility that changes in peripheral nerve excitability contributed to the observed reduction in motor cortex excitability cannot be absolutely discounted.
To determine changes in spinal reflex excitability of the soleus and fibularis longus muscles before and after fibular taping intervention.
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