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Changes in enzyme activity can result from changes in the milieu in which the enzymes operate (such as temperature and pH, and concentrations of cofactors, substrates, products, competitors, ions, phospholipids and other molecules).
In vivo, increases in enzyme activity can result from increased synthesis of enzyme due to increased expression of the mRNA coding for the enzyme, or from changes in the milieu in which the enzymes operate (such as temperature and pH, and concentrations of cofactors, substrates, products, competitors, ions, phospholipids and other molecules).
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In addition to causing about two-thirds of its members to quit between 1906 and 1910, the radicalization of the FVdG also correlates to a slight change in the milieu, industries, and regions from which the organization drew its members.
First, there is a temporal change in the milieu from neonatal to adult retina, which leads to a progressive decline in the ability of the retina to support neurogenesis [53].
We propose that the age-related increase in cancer results from a synergy between the accumulation of mutations and age-related, pro-oncogenic changes in the tissue milieu.
In this review, we first discuss tools to capture changes in the fluid milieu of organoid cultures both in the organoid exterior as well as the luminal side of the organoids.
These data suggest that differential histidine ionization may be necessary for cTnI A164H to act as a molecular sensor capable of modulating sarcomere performance in response to changes in the cytosolic milieu.
Their failure to release the drug completely in the colon may be attributed to changes in the colonic milieu because of pathological state, drug effect and psychological stress accompanying the diseased state or, a combination of these.
Despite the fact that mammals can undergo up to several reproductive cycles (primi-/pluriparous), nulliparous animals are often used and the question whether changes in the hormonal milieu subsequently affect the skeleton and influence the outcome of intervention studies is often neglected in study designs.
While the pore domain achieves sensitivity to a variety of changes in the environmental milieu through docking sensor domains, the output of the pore domain is always uniform: the opening and closing of the gate, through which passive and selective K+ flux turns on and off.
She said her choice was "in no small part due to changes in the academic milieu" and the "attack" on the faculty magazine.
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