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Patients' headache diaries were used as a source to document changes in the efficacy variables during the treatment period.
Thus, both habituation and dishabituation can be explained in part and perhaps entirely by changes in the efficacy of specific excitatory synapses.
A similar relationship may exist in the mammalian spinal cord, the activity of central neurons and non-neuronal cells modulating local translation in primary afferents and generating long term changes in the efficacy of sensory transmission through activation of receptors such as mGluR5 [65] [685]–[68] or the 5HT3 receptor [69], [70].
The molecular events that determine changes in the efficacy of endocrine therapies are not fully understood [ 5, 6].
Importantly, the concomitant use of medication for these conditions is not associated with any noteworthy changes in the efficacy and safety of vardenafil.
In addition, chronic pharmacological and genetic inactivation of MGL induces substantial changes in the efficacy of synaptic endocannabinoid signaling (Chanda et al., 2010; Tanimura et al., 2012).
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The rapid induction of synaptic homeostasis is independent of new protein synthesis and does not require evoked neurotransmission, indicating that a change in the efficacy of spontaneous quantal release events is sufficient to trigger the induction of synaptic homeostasis.
Stimulation of PI hydrolysis in the male dorsal hippocampus was only slightly affected by PRS, which induced a small reduction in the efficacy of 1S,3R-ACPD, but no change in the efficacy of DHPG (Fig. 7A,B).
The purpose of the study was to discover whether participation in an interactive course would result in a change in the efficacy beliefs of FPs to treat obesity.
The small decline in Cmax with weight did not appear to account for the larger magnitude of change in the efficacy measures with weight.
One likely interpretation of an aging shift in expression of a CORT-sensitive gene appears to be a change in the efficacy of CORT signaling.
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CEO of Professional Science Editing for Scientists @ prosciediting.com