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Table 1 This table provides an overview of the bone marrow changes in the disease course of MM, based on information obtained from conventional MRI (signal intensity on T1- and fat-suppressed T2-weighted images), dynamic contrast-enhanced MRI (time-intensity curves and semi-quantitative parameters) and diffusion weighted images (apparent diffusion coefficient (ADC), b0 and b1000 images).
Although there are a few limitations as in any long-duration study due to changes in the disease pattern, which have also been studied, our study has shown that the occurrence and frequency of various ocular opportunistic infections in developing nations such as India has significant variations from those reported in Western literature and need to be managed accordingly.
The NGS may explain some of the missing heritability, but part of the heritability is likely to be explained by other mechanisms such as gene gene interactions, gene environment interactions and epigenetics (changes in the disease or in the gene expression caused by mechanisms other than changes in the underlying DNA sequence [45]).
Moreover, epidemiological changes exceed quantitative changes in the disease burden and are also characterized by changes in the disease course.
Important epidemiological changes in the disease have occurred during the past decades [ 5, 6].
Using data from an entire calendar year avoids bias due to seasonal changes in the disease.
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Thus, the gene expression data analysis performed here revealed the changes in the disease-imprinted ONHAs, an experimental strategy that is often implemented by other investigators working with human diseases [ 24, 25].
Changes in conventional therapy were permitted during biologic therapy at the discretion of the patient's treating rheumatologist; however, no changes in the disease-modifying anti-rheumatic drug dosage were made during the study.
Examinations determining how measures of these alterations in surrogate tissues relate to changes in the disease-targeted tissues will provide a clearer understanding of whether it is the changes in target tissues or potentially in the surrogate tissues themselves that are playing a contributory role in disease.
What has changed in the disease?
"It's a dramatic change in the disease," said Sonal Munsiff, assistant commissioner for the Tuberculosis Control Program at the New York City Department of Health.
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