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We investigated measures which can be used to evaluate the effect on cycling performance of changes in stimulation parameters, and which might therefore be used to optimise them.
CIC responses to both the platinum ring and high density electrodes were recorded and differences in activity to changes in stimulation intensity, thresholds and frequency coding of neural activation were examined.
This dispersion may be due to a differential susceptibility of different cortical sites to changes in stimulation parameters.
Starting from 100 TMS/hd-EEG sessions recorded in 10 healthy subjects, we performed 62 C comparisons (22 for changes in stimulation site, 20 in stimulation intensity and 20 in stimulation angle) and 30 NC comparisons (10 same-day and 20 one-week-apart recordings with the same stimulation parameters).
Separate experimental evidences have suggested that TMS-evoked potentials have a certain degree of sensitivity to changes in stimulation parameters, such as location [10], [12], [17], [18], intensity [13], [19] and direction of the induced current with respect to the cortical surface [15].
Optimization of the VNS protocol may include changes in stimulation frequency [ 1] and extending the duration of stimulation beyond 15 min of reperfusion.
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In light of the studies on the tail artery model cited above, our attention was directed toward the possibility that age-related changes in stimulation-evoked NA release is possibly due to changes in calcium regulation in the nerve endings.
ROC analysis showed that an optimal DI threshold of 1.67%, yielded a 96.7% accuracy (95.1% sensitivity and 100% specificity) of TMS-evoked potentials in detecting whether a change in stimulation parameters occurred, or not.
As more clearly shown in Figure 1, during the transition to 4 Hz, there is a rapid decline in force production of the 1st beat following a change in stimulation rate followed by a slower further increase until force stabilizes.
Our previous studies and other studies investigating PMv-M1 connectivity have shown that a change in behavioural context is sufficient to cause a complete reversal of the influence exerted by PMv over M1 (Buch et al., 2010, J Neurosci; Buch et al., 2011, J Neurosci; Davare et al., 2009, J Physiol), even in the absence of a change in stimulation parameters.
These changes resulted in stimulation of full photosynthetic performance.
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