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After 150 min, changes in skin hydration were 24.5, 31.9, 39.3, 43.6 and 72.8% for formulations A, B, C, D and E, respectively.
The absorption of some topically applied drugs and cosmetics may be improved due to increased skin hydration [32, 33]. Figure 3 Effect of LNE on changes in skin hydration after incorporated into o/w cream (mean SD,n = 3).
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The percent change in skin hydration was calculated with the following equation: ∆% = (Q t − Q 0 /Q 0 × 100.Q t was the hydration value after application time t, and Q 0 was the hydration value before application.
Human populations differ in skin hydration, hair follicle density, and lipid production.
The corresponding mean differences from baseline (ie, improvement in skin hydration) are summarized in Table 2.
No significant variation was found in skin hydration measured at 0.5 mm of depth.
No significant differences were observed in skin hydration at both sites between the groups.
Dermal fibroblasts also synthesize HA, which plays an important role in skin hydration.
The objective measurements in the facial skin showed significant improvements from baseline in skin hydration (P<0.05), dermal ultrasound density (P<0.001), and reduction of skin pH (P<0.05).
Accordingly, through an extensive literature search, we identified the genes that encode proteins involved in skin hydration, skin elasticity, and antioxidant capacity of the skin.
Our results indicate that improvement in skin hydration and suppression of the release of pro-inflammatory cytokines in skin might be the mechanism by which sericin improves UP.
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