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Work in rodents has led to the identification of numerous changes in signalling potentially implicated in L-DOPA-induced dyskinesis (LID) [2].
These changes in signalling pathways indicate further differences in mechanobiology between these cartilaginous cell types.
We have used some of the LOESS-smoothed [ 9] data to examine bulk changes in signalling pathway components throughout the depth of the epidermis.
Haploinsufficiency of NF1 fosters a permissive tumorigenic environment through changes in signalling between cells, however the intracellular mechanisms for this tumor-promoting effect are less clear.
In addition to its effects on pillar and Deiters' cell differentiation, changes in signalling through FGFR3 also affect outer hair cell differentiation.
Could changes in signalling specificity upstream of NF-κB result in a shift in the ratio of activated NF-κB isoforms with subsequent changes in target gene expression and cellular phenotype?
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The mechanistic changes in signaling derived from this dataset are organized by receptor in the diagram shown in Fig. 3B.
Interestingly, individual transport factors displayed unique profiles when their distribution was analyzed in response to stress or changes in signaling.
Thus, changes in signaling detected by phospho-specific flow cytometry correlated with relevant downstream transcription events in primary immune cells.
This suggests that axon guidance controlled by Tsc-Rheb-Tor is sensitive to incremental changes in signaling.
The changes in signaling reactions correlated with receptor expression.
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