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Tumours were perfused with a physiological buffer of known viscosity and changes in perfusion pressure were recorded at different perfusion rates in an ex vivo system.
Outcome measures: Changes in perfusion pressure due to constrictory or dilatatory responses.
Autoregulation is defined as the intrinsic ability of organs to maintain a constant blood flow despite changes in perfusion pressure [8].
Analysis of the model indicates the existence of an optimal mean arterial pressure which minimizes the sensitivity of the flow to changes in perfusion pressure across the frequency spectrum of physiological oscillations.
Postural changes have also been used to induce acute changes in perfusion pressure.
Blue field entoptic technique has been used to study vessel reactivity during changes in perfusion pressure.
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Any change in perfusion pressure was noted after each dose.
Alterations in perfusion pressure, representing changes in resistance vessels of the mesentery, were displayed on a PowerLab/4SP computerized data acquisition system (AD Instruments, Charlgrove, Oxon, UK), and data were analysed using Chart version 5 software (AD Instruments).
Since tumour red blood cell flux and oxygenation changes may be due to alterations in perfusion pressure, MABP was also monitored over the observation period.
The CRA, as a smaller calibre vessel, is more sensitive to fluctuations in perfusion pressure, mostly due to IOP change.
Cerebral autoregulation refers to the capacity of cerebrovascular beds to maintain constant perfusion despite changes in cerebral perfusion pressure and may also be defined in terms of changes in vascular resistance or arteriolar calibre in response to fluctuations in perfusion pressure.
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