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Researches have described some apoptosis-like characters upon Al treatment in plant cells, including the appearance of DNA ladder, changes in nucleus morphology, and the fragmentation of nucleus (Panda and Matsumoto [2007]).
In response to changes in nucleus location, cytoskeletal structures and integrins might be solicited for cell adaptation.
It was found also that the increasing doses of IPC lead to dramatic changes in nucleus and microtubule network in sensitive plants.
In general, apoptotic cells have obvious morphological changes in nucleus and cytoplasm, including bubbling of cell membrane, degradation of cell nuclei with widespread damage of chromatin, and fragments of DNA caused by Ca2+ dependent endonuclease [ 34].
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Pretreatment with paeonolum significantly attenuated the MPP+-induced morphological changes in nuclei of the PC12 cells.
Interestingly, there were 2 related facts to be considered: (1) it was shown that transfecting thyroid cells with RET produced morphological changes in nuclei that mimicked those seen in PTC [ 27]; (2) it is curious that the RET gene is not expressed in the thyroid follicular cells from which PTC develops, but rearrangements of the RET are found in PTC cases [ 28].
MKN45 cells were treated with either Srb-ODN or AS-HIF-1 α-ODN and then cultured under hypoxia for an additional 48 h. Figure 6B shows fluorescence microscopic observation of the morphological changes in nuclei, including DNA fragmentation and chromatin condensation.
The standard deviation signified the change in nucleus size or vessel wall thicknesses, respectively.
We report a strong relationship between impulsivity on the 5-CSRTT and neuronal changes in the nucleus accumbens core, implicating alterations in GABA-containing neurons in this region.
DAPI staining performed to analyze morphological changes showed DNA fragmentation and an unusual change in nuclei of HT29 cells, an early apoptosis phenomenon probably, after treatment with IC50 value of SN38-PEG-PLGA-Ver nanoparticles.
When human HepG2 hepatoma cells were treated with silica nanoparticles, morphological changes in the nucleus and induction of apoptosis was observed [51].
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