Sentence examples for changes in modification patterns from inspiring English sources

Numerous changes in modification patterns have also been observed at the level of posttranslational histone modifications [109].

Weiterer, S. et al. Sepsis induces specific changes in histone modification patterns in human monocytes.

We examined changes in histone modification patterns in response to IL-4 stimulation, namely trimethylation of lysine 4 (H3K4me3) and acetylation (H3Ac) of histone 3, using ChIP Seq analysis of a total of 496 279 125 36-bp single-end read tags (Table  4).

Generally, changes in histone modification patterns were reported in a variety of tumors and correlated to tumor stage and prognosis, however with contradicting results [109].

Further studies indicated that changes in histone modification patterns rather than DNA methylation alterations were involved in this process.

ChIP Seq analysis has also been used to comprehensively assess chromatin status by monitoring changes in histone modification patterns.

This is exemplified by the increasing use of powerful genome-wide mapping technologies that have revealed numerous associations between changes in epigenetic modification patterns and cell fate transitions [ 7– 9].

Furthermore, transcription itself leads to changes in the modification pattern of the underlying chromatin [29].

Subsequent changes in histone modification pattern are observed as the germline develops and produces gametes, with dramatic increases in many histone activation marks (reviewed by Van Wynsberghe and Maine 2013).

Changes in the patterns of these modifications are associated with chromatin remodelling and can result in changes in gene expression through increasingly understood mechanisms (Lachner et al, 2003).

It became increasingly evident that cancer formation and persistence may not only be caused by genetic mutations but also because of changes in the patterns of epigenetic modifications.