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There was no relationship between adverse effects of dovitinib treatment and identifiable changes in miR patterns.
Moreover, no relationship was found between the adverse effects of dovitinib listed in Table 1 and the changes in miR patterns after dovitinib.
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We hypothesized that changes in circulating miR patterns can indicate dovitinib treatment responses, resistance to treatment, or adverse effects.
Changes in miR expression patterns and tumor sizes were compared.
miR expression profiles revealed changes in miR expression during cardiac differentiation of MiPS (Fig. 3a).
AC-induced changes in miR-34a and miR-30 concentrations reflect cell death and could mechanistically explain one aspect of the fibrosis associated with AC-induced cardiomyopathy.
The fold changes in miR-17 and miR-19a levels were calculated as log2−ΔΔCt.
We also observed changes in miR-957, miR-970, miR-980, and miR-33, among others (Additional file 2, Table S1).
Pre-docetaxel levels of miR-200b and miR-200c, and post-docetaxel changes in miR-222 and miR-20a, were associated with both PSA response and overall survival.
To explore the possibility that the global changes in expression patterns observed after miR-7 or miR-128 transfection were the result of direct targeting, we first computed the percentage of the down-regulated genes potentially regulated by miR-7 or miR-128 as predicted by three major target prediction algorithms (miRanda, TargetScan, and PicTar).
Here, we further investigated the four miRNAs with the most significant formaldehyde-induced changes in expression:miR-33, miR-330, miR-181a, and miR-10b.
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