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The strand compositional asymmetry (GC- and AT-skew) is usually considered to be associated with cytocine deaminations (C->T changes) in LES as a consequence of different exposure as single-stranded DNA.
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The changes in ling diet with depth seem reasonable, and appear likely to be a direct response to changes in prey availability.
However, only changes in LE muscle and MU muscle were statistically significant.
For activity cliffs based upon our preferred definition, one would hope that favorable changes in LE might be observed in many instances.
LE and LP power tended to improve in both groups; there was no statistically significant difference in the change in LE and LP power between groups (P=0.602 and P=0.989, respectively).
Fundus examination revealed optic disc hyperemia and a shallow ERD in the posterior pole in the RE and diffuse depigmentation producing a sunset-glow appearance with some pigmentary changes in the LE (Fig. 1).
Although it appears plausible that trends in cigarette consumption have played a decisive role in the observed changes in GD in LE since the middle of the 20th century, it seems rather unlikely that smoking is also responsible for most of the overall male excess in mortality in each population of the developed world.
Direct injection of human cancer cells into the mouse tibia or femur allows consistent development of bone metastases and can replicate tumor-induced changes in murine bone (Le Gall et al., 2007; Zheng et al., 2008; Ooi et al., 2010).
To assess trends, we estimated annual change in HLY, LE and the proportion of remaining life spent healthy (HLY/LE) and 95% confidence intervals from the country and sex-specific linear regression models.
Because of the different diets, changes in the abundance of ling and hake, brought about by exploitation for example, could have quite different effects on the ecosystem.
Here, we show that the topology of these reactions is profoundly affected by subtle changes in the hybrid recombination site les.
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