Sentence examples for changes in functionally from inspiring English sources

Additionally, some cells may lose the function of the target-gene product because of changes in functionally essential amino acids caused by the insertion and deletion of nucleotides.

This ε-GFP subunit fragment contained no changes in functionally important sequences [37].

The online analysis tools The Database for Annotation, Visualization and Integrated Discovery (DAVID; [61] and Ingenuity Pathway Analysis (IPA; from Ingenuity Systems Inc., Redwood City, USA; http://www.ingenuity.com) were used to uncover changes in functionally interconnected genes from a list of the most differentially expressed genes (Further description in Text S1).

Changes in functionally important heterozygosity may only be detectable at the gene/haplotype level.

Below, we describe the conformational changes in functionally important regions of each motor domain starting with the nucleotide-binding site, from which all other conformational changes emanate.

First glimpses into the evolution of reptile genomes (endothermic and ectothermic) have revealed unique genomic attributes such as microchromosomes, the evolution of gene structure and gene synteny [ 12- 14], as well as dramatic evolutionary changes in functionally important genes [ 15].

Adaptive amino acid changes occurred in functionally important regions of Rubisco that interact with Rubisco activase, a chaperone which promotes and maintains the catalytic activity of Rubisco.

First, many splicing changes occur in functionally related conditions, such as CNS or muscle tissues.

In conclusion, the results of this work suggest a gradual accumulation of genomic oligonucleotides by molecular drive towards overrepresentation due to the combined effects of mutation, the function of the oligonucleotide and some of its mutated forms, and weak selection against changes in the functionally unconstrained regions of the genome.

Underrepresented oligonucleotides, however, seem to be gradually eliminated by a molecular drag emanating from the combined effects of mutation, the negative effect of the oligonucleotide and some of its mutated forms on the fitness of the carrier, and selection against changes in the functionally constrained regions of the genome.

Third, another characteristic of AS datasets not easily incorporated into standard clustering methods, is that exons may exhibit a combination of splicing changes in several functionally related tissue groups, such as muscle and CNS (Zhang et al., 2008), but occurrence of regulated splicing changes across cellular conditions is expected to generally be sparse.