Patients who underwent surgery or received radiotherapy appeared, by evaluation of the HR, to have an even more dramatic change in fate than was apparent on univariate analysis.
Ngn3-null mice also displayed an accompanying increase in Npy+ cells in the ARC that is suggestive of a change in fate of developing ARC cells from Pomc-expressing to Npy-expressing (Pelling et al., 2011).
If the mechanism of tumour formation in response to constitutive Notch signalling is indeed due to changes in cell fate decisions, there may be examples in which aberrant signalling causes cells to adopt a nonproliferative cell fate and, hence, does not lead to tumour formation.
Further, we show that Wnt-dependent changes in cell fate can be decoupled from Wnt-dependent changes in cell shape.
Thus, it is possible that inhibition of commissural axon outgrowth observed above is due to the changes in cell fate or the defects in differentiation of commissural neurons.
Gastrulation is a critical process during early vertebrate development involving changes in cell fate and cell behavior to generate the three germ layers of the embryo [1].
To exclude the possibility that the observed defects in axon guidance were due to changes in cell fate in Wnt mutants, we carefully examined several features of D-type neurons.
Several mouse knockouts for these homeobox genes show changes in the fate of motoneurons, alterations in the migratory behavior of motoneurons, and defects in motor axon extension [24], [39], [40], [41].
Altered development of CD4+ naïve T cells in the absence of Itk may be a consequence of reduced TCR signaling, resulting in reduced expression of the transcription factor, Th-POK, a master regulator of CD4 commitment, and increased expression of Runx3 with accompanying changes in cell fate decision.
