Sentence examples for changes in compounds from inspiring English sources

Results from an mGlu5 receptor functional assay, using calcium fluorescence, revealed varying efficacies and potencies that provide evidence that subtle changes in compounds within a close structural class can have marked effects on functional activity including switches in modes of efficacy (i.e., negative to positive allosteric modulation).

So far, we did not find changes in compounds that would be expected to be synthesized through P450 enzyme activity (hydroxylation and oxidation).

To avoid potential metabolites in vivo that might possess switches in the mode of pharmacology, it is imperative to establish whether subtle structural changes in compounds in this series of non-MPEP site ligands have a similar propensity to display fundamentally different modes of pharmacology.

The color polyhedra surround those lattice points where the QSAR strongly associates changes in compound field values with changes in biological potency.

Since the constitutive promoter was used for the modification, changes in compound contents were expected in the whole plant body.

Figure 1 illustrates small chemical changes in compound pairs leading to large potency differences that are captured by MMP-cliffs.

Experimentally, the duration cells are in contact with a compound and the changes in compound concentration do not have a dramatic effect on single gene targets.

Matched molecular pairs (MMPs) are widely used in medicinal chemistry to study changes in compound properties including biological activity, which are associated with well-defined structural modifications.

We used internal standards to detect and correct changes in compound concentrations during the chemical preparation and injection of the extracts into the GC-MS run.

The smoothing model used in the correction algorithm must strike a balance in having enough flexibility to follow metabolism related changes in compound concentrations while avoiding undue influence from deviating observations.

This careful analysis gives them a much clearer picture of the changes in compound promiscuity over time, and reveals a low level of off-target activity and only a slight increase with time.