Sentence examples for changes in compound from inspiring English sources
The color polyhedra surround those lattice points where the QSAR strongly associates changes in compound field values with changes in biological potency.
Figure 1 illustrates small chemical changes in compound pairs leading to large potency differences that are captured by MMP-cliffs.
Since the constitutive promoter was used for the modification, changes in compound contents were expected in the whole plant body.
We used internal standards to detect and correct changes in compound concentrations during the chemical preparation and injection of the extracts into the GC-MS run.
Experimentally, the duration cells are in contact with a compound and the changes in compound concentration do not have a dramatic effect on single gene targets.
Matched molecular pairs (MMPs) are widely used in medicinal chemistry to study changes in compound properties including biological activity, which are associated with well-defined structural modifications.
Results from an mGlu5 receptor functional assay, using calcium fluorescence, revealed varying efficacies and potencies that provide evidence that subtle changes in compounds within a close structural class can have marked effects on functional activity including switches in modes of efficacy (i.e., negative to positive allosteric modulation).
So far, we did not find changes in compounds that would be expected to be synthesized through P450 enzyme activity (hydroxylation and oxidation).
To avoid potential metabolites in vivo that might possess switches in the mode of pharmacology, it is imperative to establish whether subtle structural changes in compounds in this series of non-MPEP site ligands have a similar propensity to display fundamentally different modes of pharmacology.
Trend simulation was reduced to four general parameters – overall trend shape, maximum compound concentration, percent change in compound concentration, and measurement variability.
By profiling a broad swath of tuber phenylpropanoid metabolism it was possible to observe how changes in one compound or compound class affected the overall pathway.
