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There is, therefore, a lack of information on long-term trends in gestational age alongside birthweight, making it impossible to meaningfully interpret temporal changes in birthweight.
The charts currently used in Scotland are based on data from the 1970s and require updating given changes in birthweight and in the measurement of gestational age since then.
The lack of information on some important determinants of fetal weight at birth such as maternal height, maternal smoking and exposure to environmental tobacco smoke, which have changed over time thereby affecting changes in birthweight, is disappointing.
Without gestational age, interpretation of trends in birthweight could be misleading, as it is not possible to disentangle whether changes in birthweight are attributable to changes in rates of preterm birth or to changes in actual fetal growth.
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The change in birthweight ≥ 4500 g showed a similar pattern.
Changes in abnormal birthweight may contribute to the current and future burden of chronic diseases, given the potential health risks of abnormal birthweight.
In order to develop more effective prenatal care intervention to improve both mothers' and children's health, a better understanding of changes in birthweigh and the risk factors of abnormal birthweight in the Chinese population is needed.
There is no clear trend of change in low birthweight percentages during this period of time (P > 0.05), though an increase in very low birthweight percentage (birthweight < 1500 g) was observed (data shown in Table 1).
There has been no significant change in average birthweight in the past 15 years.
The sample size calculation is based on detecting changes in primary outcome of birthweight.
Thus, we take p j (x) to be a fourth-degree polynomial, which accommodates up to two changes in convexity for each birthweight-specific mortality curve.
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