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Thus, the increase in PPV over time was mainly due to an increase in specificity, which reflected changes in antibody levels both in the cases and controls.
To study changes in antibody levels, linear mixed models were built; time since diagnosis, use of immunosuppressants, active disease, occurrence of complication, and IBD-related surgery were included in the models.
Changes in antibody levels over time were analysed by Wilcoxon's signed-rank test.
In case of multiple specimens from one dog, collected during several months or years, we controlled the results for possible changes in antibody levels.
One earlier study reported the absence of a relation between changes in antibody levels and changes in disease activity in the same time period [ 2].
We tested the sensitivity of our results to changes in the sampled size and in our ability to detect small changes in antibody levels.
Similar(47)
Overall, after adjustment for covariates, the type of supplementation did not influence antibody levels at 36 gestation weeks or the rate of change in antibody levels from enrolment to 36 weeks.
The change in antibody levels compared with change in BAS indexes and MRI change from 2006 to 2010 also did not show any correlation (P > 0.01).
The change in antibody levels was considered clinically significant when antibodies seroconverted from negative to positive or when positive antibody levels increased and at least doubled during the gluten challenge.
Change in antibody levels differed for IgG1 and IgG3 over time, and there was an inverse relationship of IgG1 to IgG3 antibodies in the sera of the SpA patients.
Neither low nor moderate to high anti-CCP titer, or relative change in antibody levels, correlated with higher risk of radiographic damage, or with outcome measures of disease activity and severity [ 18, 31].
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