Driven by the urgent need in practical applications of stimuli-responsive nano-carriers for intracellular drug delivery, the design and development of advanced polymeric micelles capable of responding to the intracellular environment (e.g., ions, proteins, enzymes, and pH changes) has represented a promising strategy as well as a new task in this research field during the past decade.
The so-called nuclear option would have represented a change in Senate rules.
It was the second such amnesty in a month, and though rights groups say hundreds of prisoners were released under the first one, a ferocious crackdown that has killed 1,400 people and led to the detention of more than 10,000, by activists' count, has overshadowed any real change that the amnesty may have represented.
His charismatic presence an unorthodox style have represented a change from the type of politician Americans have grown increasingly impatient with, which has in turn made him quite popular with conservative voters.
19 Employment and support allowance and before it the new Pathways to Work programme for new incapacity benefit claimants have represented a change in emphasis from what people with limited health cannot do to what would they could do.
The winner, Roch Marc Christian Kaboré, may not have represented a huge change from Compaoré but what really mattered was that for the first time in their history, the Burkinabé got to choose a leader for themselves.
Alfred Hitchcock's Kaleidoscope In the mid-1960s, withisis career at a low ebb following the critical failure of Marnie and an ambivalent response to Torn Curtain, Alfred Hitchcock worked on a groundbreaking experimental film that would have represented a radical change in his style-possibly heralding a new late phase of cinematic creativity.
The action highlighted just how politically fraught many pride celebrations have become, and how 2017 may have represented a sea change in the trajectory of the pride movement in general.
It is, however, unlikely that the inclusion of cohabiting couples would have represented a substantial change of the results.
These clinical signs and symptoms must have represented a clear change from the baseline clinical status of the participant and must have been accompanied by either failing cardiac output as determined by peripheral hypoperfusion (in the absence of other causes such as sepsis or dehydration) or peripheral or pulmonary edema requiring intravenous diuretics, inotropes, or vasodilators.
