Previous studies have implicated changes in miRNA expression in the regulation of development and the induction of diseases such as cancer.
Recent advances in cancer biology have implicated changes of calcium-binding protein expression as an important mechanism controlling cell proliferation in HCC.
Previous studies have implicated changes in collagen levels as an important contributory factor to scleral remodeling and axial elongation, prompting the authors to investigate collagen expression in the mutant mice.
The fidelity of correct nucleotide incorporation into damaged DNA is essential for Pol β repair function, and several studies have implicated conformational changes in Pol β as a determinant of this repair fidelity.
Studies of connectivity to date have implicated connectivity changes in such conditions as schizophrenia [1], depression [2], autism [3], and reading disorders [4], [5].
In landmark cases, focused candidate gene studies have implicated regulatory changes in trait differences between species (Marcellini and Simpson 2006; Hanikenne et al. 2008; Booth et al. 2010; Werner et al. 2010).
Studies have implicated TIA in changes in function [ 8- 10], reduced quality of life [ 11, 12], elevated levels of fatigue, anxiety and depression [ 8, 13], and other negative psycho-social outcomes [ 9, 14, 15].
While about 20 of these genetic changes have been implicated in aging in other animals, the rest of the genes' direct role in life span has not been investigated.
Epigenetic changes have been implicated in the control of wound healing [14], [15].
DNA structural changes have been implicated in the regulation of Drosophila Timeless in response to circadian photosensitivity [61], [62].
