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It is more likely that the changes have been induced by biomarker release from reservoirs in response to the medication, for example from interstitial space, or cell cytoplasm.
In the absence of a structure of MglA bound to GppNHp alone, which we were unable to obtain, we cannot exclude that any of these structural changes have been induced or, more likely, stabilized by binding to GAP.
Recent research showed that changes in neuronal activity might underlie tinnitus pathology, but our knowledge of the precise neural substrates of tinnitus is still limited also because studies have difficulties to separate what changes have been induced by hearing loss and what are specifically associated with tinnitus [ 1, 12].
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The chances are that even this is still a random process, and that offspring born with such environmentally induced changes are no more likely to benefit than if those changes had been induced by a chemical or a dose of radiation.
However, genetic or pharmacological manipulation of molecular signaling pathways does not, by itself, ensure that function will be altered because of physiological redundancy [ 38], even under conditions in which some other phenotypic change has been induced, including lifespan extension.
The information was classified according to the changes which have been induced by research results, in particular, impact on informed decision-making, the dissemination of results, and barriers and facilitators to the translation of research.
Taken together, these results indicate that a significant conformational change may have been induced by γ-irradiation that now propitiates the formation of NLP by γ-BSF even under metastable conditions.
These pathological changes, however, may have been induced by overexpression of human APP or undetected extracellular Aβ.
In these P2X7-receptor – expressing cells BzATP augmented apoptosis without evoking inflammatory changes that potentially could have been induced by activation of the P2X7 receptor [ 11, 12].
In an experimental setting, inflammatory changes in the prostatic gland have been induced by injecting C. trachomatis directly into the prostatic gland [ 15].
Therefore, some phenotypic change (that is dedifferentiation) may have been induced, as is known to occur for articular chondrocytes.
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