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Random neutral drift of aa sequences in proteins has long been established [27], and mapping of such changes has been described using neutral networks [28].
Only a single case of extensive, mitochondrial-specific rate changes has been described, in the angiosperm genus Plantago.
The sensitivity of systemic venous return to respiratory-induced changes has been described in the classic experiments by Guyton and colleagues [ 22, 23].
A cluster of families with mesial temporal lobe epilepsy with hippocampal changes has been described in Brazil (Andrade-Valença et al., 2008).
Inactivation of CDKN2A by genetic and epigenetic changes has been described in melanoma, squamous cell carcinoma, breast cancer and Hodgkin disease (Soufir et al, 1999; Brown et al, 2004; Debniak et al, 2007; Sinha et al, 2008).
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Several changes have been described in septic patients (Table 1).
Following an asphyxial event with sudden hypercapnia and hypoxia, several hemodynamic changes have been described [4].
Inflammatory changes have been described in different affective episodes, as well as in the euthymic phase of Bipolar I Disease.
Distinct peri-operative changes have been described in RCC patients, e.g. a down-regulated intensity of monocytic HLA-DR molecules [8].
The meteoric origin, recharge timing and resilience of the groundwater to short-term climatic changes have been described (Wirmvem et al. 2014a).
Osteoarthritic changes have been described to be mostly restricted to type I and type II injuries, since the greater separation of the bone ends in higher-grade injuries may prevent the development of this complication [31].
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