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The suggested biomarkers include somatic or germline gene variants, expression changes, functional deficiencies, and abnormalities in chromosomes.
Out of 7,027 unigenes with EMS changes, functional annotation was available only for 240 unigenes (wheat unigene build # 63).
9. Structural changes, functional impairment, extra-articular manifestations, comorbidities and treatment risks should be considered when making clinical decisions, in addition to assessing measures of disease activity.
It is therefore more likely that an assessment of structural changes, functional ability and pain are collectively needed to accurately predict who will require TKA [ 7, 24].
It should be cautioned that, although they have interesting potential TF site changes, functional association with any disease state has also not been determined.
In addition to structural vascular changes, functional mechanisms associated with endothelial dysfunction may also contribute to the impairment of baroreflex sensitivity associated with arterial stiffness (21).
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Moreover, deformation can be created artificially to change functional properties of carbyne since carbyne tension results in a change of the band gap [13].
Transcripts representing three consistently changed functional classes were examined using QPCR (Fig. 3).
To address these difficulties, methods that allow ad-hoc detection of changed functional GO categories have been evolving.
Table 1 shows that both the number of significantly changed functional connections, as well as the average magnitude of changes, and thus also PI's, were very similar.
Both types of stimulation yielded a similar fraction of significantly changed functional connections and the magnitude of changes agreed very well (Table 1).
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