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It appears to be a valid and useful tool, able to measure changes following therapy and whatever the kind of therapy, based on infraclinical information about the patient.
We evaluated whether larger changes following therapy were seen in the putative epithelial toxicity biomarker CK18 at higher doses of doxorubicin.
In order to document the changes following therapy a revised 14 item version of the questionnaire was administered to a further group of 44 participants with laryngeal dysfunction syndromes.
These studies have predominantly focused on changes following therapy or changes in individual patients at different time points in their disease, while this study is the first to compare global metabolites in MM, MGUS and healthy controls.
Ideally, questionnaires which measure health status should be both discriminative (able to distinguish patients with different degrees of disease severity) and evaluative (able to detect within patients changes following therapy).
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The aim of this study was to examine the effect of a vocal loading task on phonation and cough behavior in patients with chronic cough and identify change following therapy.
Mayo score improvement reached minimal clinically important difference reported for Mayo score change following therapy in inflammatory joint disease in both treatment groups [ 20].
However, while augmented insulin production as assessed with glucose and arginine stimulation continues during active treatment and is of clinical value, none of these agents have produced a meaningful, persistent change following therapy withdrawal (71, 73).
Threshold and probabilistic filtering of the data (see Additional file 2) identified 86 genes (91 probe sets) consistently, significantly and specifically altered following 5FU-based CRT and 51 genes (58 probe sets) following SCRT (see Additional File 3 for details of genes and fold change following therapy).
Further research is needed to elucidate the mechanism of 18-F-FLT uptake to be able to accurately interpret changes in uptake following therapy or histologic transformation.
Changes in SUV following therapy, however, only provide a proper measure of response in case of homogeneous FDG uptake in the tumour.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com